Table 1.

Weight and plasma data at euthanasia.

CVCPLVLP
Body weight (g)118.3 ± 2.4111.8 ± 252.2 ± 2.7*49.7 ± 2.2*
Kidney weight (mg)1121.0 ± 20.41186.8 ± 50.4764.0 ± 37.8*745.25 ± 3.7*
Kidney weight/body weight (mg/g)9.9 ± 0.110.6 ± 0.315 ± 0.9*14.5 ± 1.6*
Plasma osmolality (mOsm/kg H2O)294 ± 0.6294 ± 2.2310 ± 3.4*313 ± 3.6*
Plasma [Na+] (mmol/L)137.2 ± 1.0137.9 ± 0.7146.4 ± 2.0#145.0 ± 2.7
Plasma [K+] (mmol/L)5.6 ± 0.35.5 ± 0.35.3 ± 0.25.5 ± 0.6
Plasma [Li+] (mmol/L)NDND0.95 ± 0.141.29 ± 0.13
Hematocrit (%)34.8 ± 0.835.2 ± 0.832.2 ± 1.031.8 ± 1.2
Plasma renin ng (ANG I/L/h)2442 ± 3883242 ± 3857483 ± 894#6799 ± 3343
Cortical PGE2 (pg/mg protein)22.5 ± 1.519.2 ± 1.332.1 ± 5.323.7 ± 4.8
  • Because plasma was not sampled for rats used for fixation, n = 9–10 for body weight and cortical PGE2 data, while all plasma data are n = 4–5. Data have been analyzed with one‐way ANOVA followed by Bonferroni's multiple comparisons test. Data are presented as means ± SEM. Small groups (n < 5) were analyzed with nonparametric Kruskal–Wallis test followed by Dunn's multiple comparisons test. ND, not determined.

  • * P < 0.05 compared to the CV and CP groups.

  • # P < 0.05 CV and CP versus LV.