Table 3. Peripheral and cerebral hemodynamic parameters at selected time points (T1‐T4)
ParameterVisitT1T2T3T4P value (time point effect)P value (visit effect)
BP (mmHg)189.3 ± 8.682.2 ± 8.6a81 ± 8.1a85.7 ± 7.1a<0.0010.7
287.4 ± 1181.5 ± 11.6a80.7 ± 9.7a85.5 ± 11.5
Heart rate (bpm)165 ± 9.365.1 ± 10.664.5 ± 9.865.5 ± 100.761
264.3 ± 10.465.3 ± 11.665.6 ± 11.664.9 ± 10.6
End‐tidal CO2 (mmHg)137.9 ± 437.5 ± 3.738 ± 3.738.3 ± 3.60.390.38
238.8 ± 438.3 ± 4.338.6 ± 4.239.7 ± 5.3
DH CBV (cm·sec−1)151.2 ± 13.448.3 ± 13a48.6 ± 13.450.7 ± 13.6<0.0050.77
252.4 ± 12.949.3 ± 13a48.7 ± 13.250.4 ± 12.3
NDH CBV (cm·sec−1)153.8 ± 14.751 ± 15.1a51.9 ± 15.353.2 ± 13.4<0.0050.11
250.7 ± 12.548.8 ± 13.547.6 ± 12a48.9 ± 12.4
DH CrCP (mmHg)137.1 ± 8.830.9 ± 9.4a31.8 ± 9.4a37.9 ± 8.1<0.0010.68
240 ± 9.532 ± 11.8a32.4 ± 10.6a40.6 ± 11.1
NDH CrCP (mmHg)139.9 ± 8.834.4 ± 8.3a34.7 ± 8.2a41 ± 8.9<0.0010.6
237.8 ± 1331.3 ± 13.9a31.4 ± 13.5a38.5 ± 14.2
DH RAP (mmHg·sec·cm−1)11.11 ± 0.341.16 ± 0.351.1 ± 0.331.02 ± 0.33b0.0020.56
21 ± 0.361.09 ± 0.411.07 ± 0.40.98 ± 0.38b
NDH RAP (mmHg·sec·cm−1)10.94 ± 0.290.97 ± 0310.93 ± 0.290.88 ± 0.27b0.0330.89
20.9 ± 0.230.98 ± 0.330.98 ± 0320.89 ± 0.25b
  • Data are mean ± SD. P‐values from two‐way ANOVA for effects of time (T1–T4) and visit. BP, blood pressure; bpm, beats per minute; CBV, cerebral blood velocity; CrCP, critical closing pressure; RAP, resistance area product; ARI, autoregulation index; DH, dominant hemisphere; NDH, nondominant hemisphere.

  • a Tukey post hoc P < 0.05 compared to T1.

  • b Tukey post hoc P < 0.05 compared to T2.