Table 3. Echocardiographic data on heart geometry and function at baseline (0) age 12 and endpoint (16) age 28 weeks (mean ± SEM)
ParameterNS (n = 3)HS (n = 5)OVX NS (n = 3)OVX HS (n = 4)Effect of diet a and/or OVX b and/or time t
IVSd (mm)01.0 ± 0.071.1 ± 0.091.3 ± 0.110.9 ± 0.13
161.2 ± 0.041.8 ± 0.03d1.4 ± 0.191.7 ± 0.08a, c
IVSs (mm)01.6 ± 0.071.8 ± 0.252.1 ± 0.461.5 ± 0.21
162.1 ± 0.022.7 ± 0.132.3 ± 0.282.6 ± 0.01 c
PWd (mm)01.0 ± 0.061.1 ± 0.101.2 ± 0.180.9 ± 0.02
161.2 ± 0.112.0 ± 1.28d1.4 ± 0.111.8 ± 0.10da, c
PWs (mm)01.5 ± 0.021.6 ± 0.171.8 ± 0.161.5 ± 0.08
161.7 ± 0.132.5 ± 0.06d2.0 ± 0.182.5 ± 0.10da, c
LVIDd (mm)06.7 ± 0.086.9 ± 0.227.6 ± 0.767.5 ± 0.24
167.4 ± 0.286.8 ± 0.278.3 ± 0.147.6 ± 0.14a,b
LVIDs (mm)04.2 ± 0.024.5 ± 0.294.3 ± 0.025.2 ± 0.25
164.7 ± 0.214.3 ± 0.075.6 ± 0.174.3 ± 0.15a,b
RWT00.30 ± 0.020.29 ± 0.020.31 ± 0.030.24 ± 0.02
160.33 ± 0.020.57 ± 0.04d0.29 ± 0.000.46 ± 0.03a, c
LVMi (g/cm)00.123 ± 0.0060.119 ± 0.0080.129 ± 0.0070.114 ± 0.008
160.164 ± 0.0020.255 ± 0.012d0.185 ± 0.0110.253 ± 0.012da, c
HR (bpm)0338 ± 11327 ± 14379 ± 5363 ± 11 b
16350 ± 16363 ± 13374 ± 37368 ± 7
SV (μL)0151 ± 5156 ± 17161 ± 11172 ± 12
16191 ± 14157 ± 21223 ± 8222 ± 11 b
CO (mL/min)051 ± 2747 ± 4761 ± 4962 ± 38
1667 ± 3855 ± 1086 ± 8382 ± 55 b
EF (%)066 ± 0.663 ± 571 ± 657 ± 3
1666 ± 0.765 ± 369 ± 273 ± 2d a
FS (%)037 ± 0.535 ± 442 ± 531 ± 2
1637 ± 0.437 ± 233 ± 144 ± 2d a
MFS (%)020 ± 0.718 ± 120 ± 219 ± 0.8
1620 ± 0.614 ± 2d19 ± 0.918 ± 1 a
E to E′ ratio1615.7 ± 1.615.6 ± 0.610.0 ± 1.913.7 ± 1.3 b
  • i index tibia length.

  • a P < 0.05 for the effect of diet.

  • b P < 0.05 for the effect of OVX.

  • c P < 0.05 for the effect of time.

  • d P < 0.05 versus, corresponding NS.