Table 2. Body mass, organ masses, blood samples, and histology at endpoint (mean ± SEM)
ParameterNS (n = 6)HS (n = 8–9)OVX NS (n = 6)OVX HS (n = 6)Effect of diet a and/or OVX b
Body mass (g)272 ± 6251 ± 7304 ± 8278 ± 5a b
weight gain (g)36 ± 7.534 ± 6.865 ± 6.560 ± 8.3 b
LV mass (g)0.76 ± 0.030.90 ± 0.050.82 ± 0.020.97 ± 0.03 a
LV mass/tibia length (g/cm)0.18 ± 0.010.21 ± 0.01c0.19 ± 0.010.22 ± 0.01ca
Lung mass (g)1.38 ± 0.041.76 ± 0.131.45 ± 0.071.69 ± 0.24 a
Lung mass/tibia length (g/cm)0.33 ± 0.010.41 ± 0.030.34 ± 0.020.39 ± 0.05 a
Kidney mass (g) 0.85 ± 0.041.13 ± 0.090.86 ± 0.02 1.07 ± 0.04 a
Kidney mass/tibia length (g/cm)0.20 ± 0.010.26 ± 0.02c0.22 ± 0.010.25 ± 0.01 a
Plasma BNP (ng/mL)0.30 ± 0.080.45 ± 0.100.37 ± 0.150.16 ± 0.03c
Plasma Creatinine (μg/mL)0.13 ± 0.020.15 ± 0.020.17 ± 0.010.13 ± 0.03
  • a P < 0.05 when analyzed according to diet.

  • b P < 0.05 when analyzed according to OVX.

  • c P < 0.05 relative to NS in the corresponding group.