Table 2. Effects of acetylcholine and sodium nitroprusside on hemodynamic parameters in early (1‐week) and late (8‐week) time points of Sugen5416/hypoxia/normoxia‐exposed PAH rats
BaselineACh (5 μg/kg/min)SNP (5 μg/kg/min)
1‐weekRVSP, mmHg70.1 ± 3.870.7 ± 3.753.1 ± 3.5*
TPRI, mmHg/(mL/min/kg)0.29 ± 0.030.29 ± 0.030.19 ± 0.02*
LVSP, mmHg119.7 ± 4.7103.2 ± 3.7*81.1 ± 1.1**,
SVRI, mmHg/(mL/min/kg)0.50 ± 0.030.42 ± 0.030.29 ± 0.02**,
8‐weekRVSP, mmHg139.4 ± 5.6114.4 ± 4.7*103.7 ± 7.1**
TPRI, mmHg/(mL/min/kg)0.99 ± 0.080.65 ± 0.05**0.60 ± 0.08**
LVSP, mmHg102.7 ± 4.982.9 ± 4.3*73.2 ± 6.3**
SVRI, mmHg/(mL/min/kg)0.73 ± 0.060.48 ± 0.05**0.38 ± 0.04**
  • Effects of acetylcholine (ACh; 5 μg/kg/min) and sodium nitroprusside (SNP; 5 μg/kg/min) on hemodynamics. Values are mean ± SEM. N=9–12 for each group. RVSP, right ventricular systolic pressure; TPRI, total pulmonary vascular resistance index; LVSP, left ventricular systolic pressure; SVRI, systemic vascular resistance index;

  • *P < 0.05 and **P < 0.01 versus Baseline, P < 0.05 versus ACh.