Table 2. Fold changes of NPs and RAAS gene expressions in ES‐HF kidney and heart
Gene nameSymbolKCKMLALV
Natriuretic peptide system
Atrial natriuretic peptide, ANPNPPA1.61.4 3.7 a 1.0
B‐type natriuretic peptide, BNPNPPB1.91.6 4.8 a 0.3
C‐type natriuretic peptide, CNPNPPC 1.5 a 0.72.8 6.1 a
Natriuretic peptide receptor ANPR11.30.61.10.9
Natriuretic peptide receptor BNPR21.20.8 1.8 a 1.0
Natriuretic peptide receptor CNPR3 2.3 a 2.5 a 1.50.9
CorinCORIN1.60.40.81.2
FurinFURIN1.21.0 3.4 a 1.8 a
Dipeptidyl peptidase‐4DPP41.40.1 3.0 a 0.8
Insulin degrading enzymeIDE1.00.9 2.2 a 1.0
Membrane metalloprotease (neprilysin, NEP)MME1.00.10.00.4
Renin‐angiotensin‐aldosterone system
AngiotensinogenAGT1.10.50.5 0.1 a
Angiotensin II receptor type I, AT1 receptorAGTR11.30.21.41.6
ReninREN 1.7 a 0.1 12.5 a 1.6
Mineralocorticoid (aldosterone) receptorNR3C20.90.60.90.8
  • Data are expressed as fold change compared to normals.

  • a P<0.05 versus normals.

  • Bold indicates significant values.