Table 3. Fold changes from normals (>5‐fold in at least one tissue type examined)
Gene nameSymbolKCKMLALV
Inflammatory cytokines and other growth factors
Tumor necrosis factor‐alphaTNF 3.6 a 1.8 22.0 a 3.5 a
Interleukin‐6IL6 24.7 a 2.5 293.7 a 40.0 a
Leukemia inhibitory factorLIF 23.0 a 42.4 a 45.7 a 3.8 a
Endothlin‐1EDN13.41.4 9.6 a 1.3
Monocyte chemoattractant protein‐1, MCP‐1CCL2 17.0 a 10.4 a 143.8 a 27.7 a
Interleukin‐1 betaIL1B 4.4 a 0.5 10.2 a 4.9
Interleukin‐10IL100.90.4 4.3 a 0.5
Interferon‐gammaIFNG 4.1 a 4.7 a 21.9 a 6.3 a
Colony stimulating factor 3CSF3 7.4 a 2.7 a 133.6 a 48.8 a
Platelet‐derived growth factor BPDGFB 11.7 a 2.4 2.3 a 0.8
Platelet‐derived growth factor receptor BPDGFRB 1.7 a 0.8 2.9 a 1.3
Vascular cell adhesion molecule‐1VCAM1 37.2 a 4.3 a 33.7 a 10.4 a
C‐reactive proteinCRP 7.1 a 1.30.03.2
InsulinINS1.31.0 7.0 a 2.8
Von Willebrand factorVWF1.00.6 4.3 a 1.3
Tissue plasminogen activatorPLAT 3.9 a 1.8 a 13.5 a 3.1 a
Plasminogen activator inhibitor‐1SERPINE1 26.5 a 12.4 a 86.7 a 28.9 a
Nuclear factor kappa‐BNFKB1 5.5 a 2.5 a 7.2 a 4.0 a
Renal inflammation and injury
Interleukin‐1 alphaIL1A 7.2 a 3.4 a
Interleukin‐8IL8 38.4 a 15.6 a
Granulocyte‐colony stimulating factorCSF3 8.5 a 3.0
Intercellular adhesion molecule 1ICAM1 55.9 a 14.7 a
E‐selectinSELE 139.0 a 53.6 a
Serum amyloid A1SAA1 13.8 a 1.5
Immediate early response 3IER3 8.6 a 3.0 a
Apoptosis
Baculoviral IAP repeat containing 3BIRC3 25.9 a 14.9 a 25.2 a 15.9 a
Fas (TNF superfamily member 6)FAS 4.2 a 1.7 8.1 a 2.8 a
TNF receptor superfamily member 12ATNFRSF12A 4.6 a 7.1 a 11.0 a 1.5
MycMYC 7.7 a 3.4 a 4.7 a 3.3 a
Fibrosis
Collagen type ICOL1A1 1.8 a 0.4 60.6 a 2.2
Collagen type IIICOL3A11.00.5 16.0 a 1.6
Collagen type IVCOL4A1 1.7 a 1.1 9.3 a 20.9
Collagen type IVCOL4A2 1.5 a 0.9 8.9 a 1.8
Fibronectin‐1FN1 1.9 a 1.0 24.2 a 2.0
Connective tissue growth factorCNGF 1.9 a 0.9 6.0 a 1.5 a
General transcription factor IIIAGTF3A 0.1 a 0.41.20.8
Integrin beta‐3ITGB3 2.8 a 0.8 10.1 a 4.1 a
Matrix metalloproteinase 8MMP8 16.5 a 3.64.16.4
Matrix metalloproteinase 9 (gelatinase B)MMP9 0.3 a 3.0 5.7 a 4.8
Matrix metalloproteinase 13MMP13 20.6 a 3.6 10.6 a 1.9
Tissue inhibitor of metalloproteinases 1TIMP1 0.3 a 1.2 15.9 a 2.5
Transforming growth factor‐beta 2TGFB2 1.2 a 1.2 6.6 a 1.6 a
Transforming growth factor‐beta 3TGFB32.20.9 10.2 a 0.9
Transforming growth factor‐beta receptor 1TGFBR1 0.2 a 1.2 6.3 a 2.0 a
Latent‐transforming growth factor beta binding protein‐1LTBP11.51.0 6.5 a 1.5
  • Data are expressed as fold change compared to normals.

  • a P<0.05 versus normals.

  • Bold indicates significant values.