Table 1. Canine characteristics
Normal (n = 4)ES‐HF (n = 4)
General information
Body weight (BW), kg21.0 ± 0.524.9 ± 1.2
Heart weight (HW), g191.9 ± 16.8176.3 ± 4.8
HW/BW8.2 ± 0.67.10 ± 0.3
Left atrium, g10.3 ± 1.115.6 ± 1.3a
Left ventricle, g129.7 ± 12.9103.2 ± 1.4
Right kidney, g59.9 ± 6.050.9 ± 4.5
Echo parameter
Ejection fraction, %62.3 ± 7.324.3 ± 3.7a
LVDd, mm41.7 ± 2.544.3 ± 3.8
Hemodynamic parameters
Heart rate, bpm108.8 ± 5.9 240 a
Mean arterial pressure, mmHg113.3 ± 2.295.5 ± 4.1a
Pulmonary artery pressure, mmHg14.3 ± 1.125.7 ± 1.8a
Right atrium pressure, mmHg2.8 ± 0.86.1 ± 1.5
Pulmonary capillary wedge pressure, mmHg5.7 ± 0.420.0 ± 1.5a
Cardiac output, l/min3.5 ± 0.42.3 ± 0.2
Systemic vascular resistance, mmHg/l/min33.3 ± 4.747.2 ± 5.6
Renal functions
Glomerular filtration rate, mL/min38.4 ± 2.832.2 ± 1.6
Urine flow, mL/min0.36 ± 0.040.22 ± 0.008a
Urinary sodium excretion, mEq/min33.7 ± 3.914.7 ± 1.1a
Urinary potassium excretion, mEq/min57.7 ± 4.127.6 ± 3.4a
Neurohumoral factors
Plasma A‐type natriuretic peptide, pg/mL24.9 ± 7.197.4 ± 21.0a
Plasma B‐type natriuretic peptide, pg/mL13.6 ± 3.535.2 ± 5.3a
Plasma cGMP, pmol/mL6.9 ± 0.922.5 ± 3.7a
Plasma ANG‐II, pg/mL10.8 ± 3.131.7 ± 4.1a
Plasma aldosterone, ng/dL4.8 ± 0.813.0 ± 2.7a
Plasma renin activity, pg/mL1.5 ± 0.410.1 ± 2.1a
  • Data are expressed as mean ± SEM.

  • a P<0.05 versus normals.

  • Bold indicates significant values.