Table 2. Gene expression in epiWAT in C57Bl/6J and FVB/N mice that were fed the chow diet or HFD. Pparg2 (PPARγ2), peroxisome proliferator‐activated receptor γ2; Pgc1a (PGC1α), peroxisome proliferative activated receptor γ, coactivator 1α; Cebpa (C/EBPα), CCAAT/enhancer‐binding protein α; Srebp1 (SREBP‐1c), sterol regulatory element‐binding transcription factor 1c; Acaca (ACCα, acetyl‐CoA carboxylase α; Fasn (FAS), fatty acid synthase; Cpt1a (CPT‐I), carnitine palmitoyltransferase I; Lipe (HSL), hormone‐sensitive lipase; Ucp2, uncoupling protein 2; Pfk‐1, phosphofructokinase 1; Pck1 (PEPCKcit), phosphoenol pyruvate kinase cytosolic; Slc2a4 (GLUT4), glucose transporter type 4; Lep, leptin; Tnf (TNFα, tumor necrosis factor α; Il6 (IL6), interleukin 6. n = 9
C57BL6/J ChowC57BL6/J HFDFVB/N ChowFVB/N HFDC57BL6/JFVB/NC57BL6/J vs. FVB/N
MeanSEMMeanSEMMeanSEMMeanSEMChow vs. HFDChow vs. HFD
Transcriptional factors
Pparg2 (PPARγ2)1.00.050.60.091.10.110.20.02P < 0.01P < 0.0001n.s.
Pgc1a (PGC1α)1.00.140.30.050.80.130.30.08P < 0.001P < 0.01n.s.
Cebpa (C/EBPα)1.00.070.60.050.80.070.20.02P < 0.0001P < 0.0001n.s.
Srebp1 (SREBP‐1c)1.00.110.90.091.40.132.10.23n.s.P < 0.05P < 0.05
Fatty acid metabolism
Acaca (ACCα)1.00.200.30.062.30.500.20.04P < 0.01P < 0.001P < 0.05
Fasn (FAS)1.00.260.40.092.50.540.20.05P < 0.05P < 0.001P < 0.05
Cpt1a (CPT‐I)1.00.241.70.202.80.296.20.73P < 0.05P < 0.001P < 0.001
Lipe (HSL)1.00.080.60.081.00.130.10.02P < 0.01P < 0.0001n.s.
Ucp2 1.00.143.00.493.70.459.20.88P < 0.01P < 0.0001P < 0.0001
Glucose metabolism
Pfk‐1 1.00.070.80.071.50.190.50.08n.s.P < 0.001P < 0.05
Pck1 (PEPCKcit)1.00.140.30.061.10.180.020.01P < 0.001P < 0.0001n.s.
Slc2a4 (GLUT4)1.00.060.40.061.20.220.050.01P < 0.0001P < 0.0001n.s.
Adipokines
Lep (Leptin)1.00.163.40.522.30.370.70.18P < 0.001P < 0.01P < 0.01
Tnf (TNFα)1.00.384.81.741.90.39192.84P < 0.05P < 0.0001n.s.
Il6 (IL6)1.00.494.10.762.80.409.01.71P < 0.01P < 0.01P < 0.05