Table 2. Two‐sample permutations of iohexol one‐compartment plasma clearance compared to iohexol plasma clearance calculated by trapezoidal, one‐, and two‐compartment models – linear regression coefficients, bias, precision, and accuracy
Sample timesIohexol one‐compartmentIohexol trapezoidalIohexol two‐compartment
R2Bias/Precisiona10% AcbR2Bias/Precisiona10% AcbR2Bias/Precisiona10% Acb
30, 600.870.02 ± 0.2772.70.860.00 ± 0.3250.00.840.04 ± 2.7969.0
60, 900.900.18 ± 0.9576.70.920.16 ± 0.9447.70.910.19 ± 0.9572.5
90, 1200.430.15 ± 0.3773.30.730.13 ± 0.4351.10.660.12 ± 0.4266.7
30, 900.97−0.02 ± 0.1291.10.96−0.04 ± 0.1566.70.940.01 ± 0.1883.3
60, 1200.82−0.04 ± 0.2353.30.91−0.06 ± 0.1966.70.95−0.01 ± 0.3254.8
  • Each animal (N = 8) at each evaluation (N = 6) is an individual data point (N = 44–48). Linear regression coefficients (R2) weighted 1/C2.

  • a Bias or absolute bias is calculated as reference method – two‐sample clearance. Precision is the standard deviation of bias.

  • b 10% Ac or 10% Accuracy is the percentage of sample values with a % bias of <10. % Bias is calculated by dividing the absolute bias by the mean of the two measures.