Table 1. Linear regression coefficients, mean bias, precision, and accuracy comparing all plasma clearance measures of both inulin and iohexol
Reference measureComparative measureR2Bias/Precisiona (mL/min)%Bias/Precisionb10% Accuracyc15% Accuracyc
Inulin trapezoidalIohexol two‐compartment0.93−0.02 ± 0.37−1.2 ± 16.455.869.8
Iohexol trapezoidal0.970.04 ± 0.233.8 ± 11.673.982.6
Iohexol one‐compartment0.960.02 ± 0.280.12 ± 13.2456.580.4
Inulin two‐compartment0.97−0.28 ± 0.25−19.9 ± 7.514.321.9
Inulin one‐compartment0.98−0.57 ± 0.37−26.6 ± 7.302.17
Inulin two‐compartmentIohexol two‐compartment0.930.35 ± 0.3518.5 ± 12.616.337.2
Iohexol trapezoidal0.970.41 ± 0.2523.3 ± 9.96.517.4
Iohexol one‐compartment0.960.39 ± 0.3119.7 ± 10.113.037.0
Inulin one‐compartment0.99−0.49 ± 0.18−6.81 ± 5.1474.591.5
Iohexol trapezoidalIohexol two‐compartment0.97−0.07 ± 0.19−5.5 ± 9.574.483.7
Iohexol one‐compartment0.98−0.02 ± 0.13−3.7 ± 8.078.387.0
Iohexol two‐compartmentIohexol one‐compartment0.980.03 ± 0.160.9 ± 7.095.395.3
  • Each animal (N = 8) at each evaluation (N = 6) is an individual data point (N = 44–48). Linear regression coefficients (R2) weighted 1/C2.

  • a Bias or absolute bias is calculated as reference method‐comparative method. Precision is the standard deviation of bias.

  • b % Bias is calculated by dividing the absolute bias by the mean of the two measures.

  • c Accuracy is the percentage of sample values with a % bias of <10 or 15.