Table 2. Weights and blood chemistry at 24 weeks age in female mice
 BTBR leanBTBRob/obBTBRob/ob + PPARBTBRob/ob + Ena
Body weight (g)34.5 (3.1)71.6 (6.1)###70.5 (10.7)71.9 (7.6)
Liver weight (g)1.7 (0.1)3.8 (0.8)###6.5 (1.5)**3.8 (0.9)
Total kidney weight (g)0.39 (0.02)0.61 (0.13)###0.63 (0.06)0.59 (0.06)
HbA1C (%)4.8 (0.2)10.5 (2.4)###7.3 (1.9)**7.8 (2.2)*
Insulin (nmol/L)0.3 (0.0)2.3 (2.6)3.4 (3.2)6.3 (5.4)
TG (mmol/L)0.5 (0.1)2.2 (1.0)###1.0 (0.2)**1.8 (0.6)
Adiponectin (nmol/L)672 (271)278 (116)###226 (95)312 (175)
  • Data are presented as means and standard deviations for the groups: BTBR lean (n = 5), BTBRob/ob (n = 11–12), BTBRob/ob + PPAR (n = 7–8), and BTBRob/ob + Ena (n = 7). ###P < 0.001 versus BTBR lean and *P < 0.05, **P < 0.01 versus BTBRob/ob vehicle control using ANOVA and Dunnett's post hoc test. Ena, enalapril; HbA1C, glycated hemoglobin A1C; TG, triglycerides.