Table 1. Serum and urine electrolyte composition of mice following a 2 week treatment with ME‐1 or control rat IgG
MeasurementControlME‐1Normal rangea
Serum
[Mg2+] (mmol/L)1.12 ± 0.011.04 ± 0.03b1.1–1.4
[Ca2+] (mmol/L)2.11 ± 0.092.24 ± 0.072.0–2.8
[Pi] (mmol/L)2.67 ± 0.012.96 ± 0.09b2.2–3.0
[Na+] (mmol/L)158.0 ± 2.9155.0 ± 2.2130–160
[K+] (mmol/L)4.90 ± 0.195.54 ± 0.254.5–7.5
Urine
Volume (mL/24 h)1.34 ± 0.121.31 ± 0.17n/a
Mg2+ excretion (μmol/24 h)23.65 ± 2.5018.52 ± 3.0n/a
Ca2+ excretion (μmol/24 h)0.30 ± 0.030.30 ± 0.03n/a
Pi excretion (μmol/24 h)91.1 ± 8.588.0 ± 6.6n/a
Na+ excretion (μmol/24 h)191.7 ± 17.5178.8 ± 22.6n/a
K+ excretion (μmol/24 h)199.3 ± 12.5202.7 ± 17.1n/a
  • a Normal serum values are based on the values provided by the Research Animal Resources at the University of Minnesota and on experiments performed in our lab.

  • b Data compared by unpaired Student's t‐test; P < 0.05 compared to control group. Data represent mean ± SE; n = 6–7.