Table 4. The proportion of variance explained in the multivariable regression models for the systolic and diastolic blood pressure response following VIGOROUS and MODERATE among African Americans
VIGOROUS
SBP
GenePolymorphismModel1PVE2P value3
NoneNoneBP response = −1.7872 + 2.1590*time + 0.0207*time^2 − 0.0320*time^3 + 16.4343*log(AASICONT) + 0.6782*Orientation 19 h SBP + 0.5765*Age0.9252
GenePolymorphismModel1Partial PVE2P value3
ACE rs1055086BP response = 2.5653 + 2.1353*time + 0.0076*time^2 − 0.0315*time^3 + 11.2080*log(AASICONT) + 0.6832*Orientation 19 h SBP + 0.4349*Age − 18.8394*SNP0.0581<0.0001
AGTR1 rs74662294BP response = −0.2841 + 1.5349*time + 0.0091*time^2 − 0.0210*time^3 + 11.1560*log(AASICONT) + 0.6298*Orientation 19 h SBP + 0.5368*Age − 18.5855*SNP + 8.5552*SNP*time + .0618*SNP*time^2 − 0.1505*SNP*time^30.05620.0006
CYP11B2 rs4546BP response = 2.3621 + 0.8792*time + 0.0024*time^2 − 0.0104*time^3 + 12.8728*log(AASICONT) + 0.6632*Orientation 19 h SBP + 0.5562*Age − 8.0779*SNP + 2.5435*SNP*time + 0.0276*SNP*time^2 − 0.0427*SNP*time^30.04570.0103
CYP11B2 rs45464BP response = −0.2841 + 1.5349*time + 0.0091*time^2 − 0.0210*time^3 + 11.1560*log(AASICONT)  + 0.6298*Orientation 19 h SBP + 0.5368*Age − 18.5855*SNPr + 8.5552*SNPr*time + 0.0618*SNPr*time^2 − 0.1505*SNPr*time^30.05620.0006
CYP11B2 rs4537BP response = −0.2841 + 1.5349*time + 0.0091*time^2 − 0.0210*time^3 + 11.1560*log(AASICONT) + 0.6298*Orientation 19 h SBP + 0.5368*Age − 18.5855*SNP + 8.5552*SNP*time + 0.0618*SNP*time^2 − 0.1505*SNP*time^30.05620.0006
ADD1 rs16843169BP response = 0.3502 + 1.2629*time − 0.0114*time^2 − 0.0164*time^3 + 13.6612*log(AASICONT) + 0.5605*Orientation 19 h SBP + 0.6071*Age − 14.0158*SNP + 6.2030*SNP*time + 0.1861*SNP*time^2 − 0.1079*SNP*time^30.05200.0023
ADD1 rs6833874BP response = 1.2998 + 2.1528*time + 0.0172*time^2 − 0.0318time^3 + 12.5206*log(AASICONT) + 0.5062*Orientation 19 h SBP + 0.5701*Age − 10.5065*SNP0.02610.0143
DBP
GenePolymorphismModel1PVE2P value3
NoneNoneBP response = −3.1187 − 4.3889*log(Endothelin) − 8.5055*log(TRIG) + 7.6938*Gender0.8577
GenePolymorphismModel1Partial PVE2P value3
ACE rs1055086BP response = −0.6785 − 2.6365*log(Endothelin) − 8.8759*log(TRIG) + 2.6364*Gender − 10.9469*SNP0.06080.0052
AGTR1 rs74662294BP response = −1.7776 − 4.0777*log(Endothelin) − 5.5915*log(TRIG) + 6.8446*Gender − 15.2493*SNP0.07600.0011
CYP11B2 rs4546BP response = 0.5261 − 3.9426*log(Endothelin) − 6.4122*log(TRIG) + 5.8313*Gender − 6.2073*SNP0.07410.0013
CYP11B2 rs45464BP response = −1.7776 − 4.0777*log(Endothelin) − 5.5915*log(TRIG) + 6.8446*Gender − 5.2493*SNPr0.07600.0011
CYP11B2 rs4537BP response = −1.7776 − 4.0777*log(Endothelin) − 5.5915*log(TRIG) + 6.8446*Gender − 15.2493*SNP0.07600.011
ADD1 rs16843169BP response = −1.7941 − 4.6642*log(Endothelin) − 8.2145*log(TRIG) + 6.5921*Gender − 7.0455*SNP0.03610.0429
ADD1 rs6833874BP response = −0.1305 −3.9535*log(Endothelin) − 5.8818*log(TRIG) + 5.0602*Gender − 7.8010*SNP0.05660.0077
MODERATE
SBP
GenePolymorphismModel1PVEP value
NoneNoneBP response = −3.2665 + 10.9273*log(INSULIN)0.6623
GenePolymorphismModel1Partial PVE2P value3
ACE rs3730036BP response = −4.1164 + 8.0972*log(INSULIN) + 11.9101*SNP0.06900.0736
CYP11B2 rs3802228BP response = −4.8800 + 8.2175*log(INSULIN) + 5.6512*SNP0.08570.0429
CYP11B2 rs38022284BP response = −4.1164 + 8.0972*log(INSULIN) + 11.9101*SNPr0.06900.0736
CYP11B2 rs6432BP response = −4.1164 + 8.0972*log(INSULIN) + 11.9101*SNP0.06900.0736
  • VIGOROUS, 100% of peak oxygen consumption (VO2peak); MODERATE, 60% VO2peak; SBP, systolic blood pressure; DBP, diastolic blood pressure; PVE, proportion of variance explained; ACE, Angiotensinogen‐Converting Enzyme, AGTR1, Angiotensin Type 1 Receptor, CYP11B2, Aldosterone Synthase, ADD1, Adducin; SNP, polymorphism; TRIG, triglycerides; AASICONT, resing ambulatory arterial stiffness index over 19 h; Orientation 19 h SBP, resting ambulatory SBP over 19 h.

  • 1Restricted maximum likelihood estimates reported; all covariates centered except for polymorphism.

  • 2Either polymorphism only (when there is no polymorphism by time interaction) or joint polymorphism and polymorphism by time effects (when there is a polymorphism by time interaction), computed using maximum likelihood.

  • 3Likelihood ratio tests for either polymorphism only (when there is no polymorphism by time interaction) or joint polymorphism and polymorphism by time effects (when there is a polymorphism by time interaction) under maximum likelihood.

  • 4Recessive model for polymorphism (i.e., SNPr = 0 if 0 or 1 copy of the minor allele; SNPr = 1 if 2 copies of the minor allele; additive genetic models used for all other polymorphisms (i.e., SNP = #minor allele).