Table 3. The blood pressure response (X ± SD)1 after versus before MODERATE compared to control over 19 h by # of Minor Alleles and Racial/Ethnic Group
Gene name (Gene symbol)Chromosome (Chr) locationVariantFunctionCADD scoreAfrican Americans (n = 14)Caucasians (n = 9)
# Minor AllelesSBPDBP# Minor AllelesSBPDBP
Angiotensinogen Converting Enzyme (ACE)Chr17q23.3rs3730036*Synonymous/Missense/Coding Transcript17.2 0 (n = 13)
1 (n = 1)
2 (n = 0)
4.7 ± 7.3
16.1 ± NA
NA
−3.5 ± 6.0
3.9 ± NA
NA
0 (n = 9)
1 (n = 0)
2 (n = 0)
−3.0 ± 6.6
NA
NA
−1.6 ± 5.2
NA
NA
rs3730038Intronic/Transcript1.614
rs3730042Intronic/Transcript1.834
rs28730840Intronic/Transcript3.486
Aldosterone Synthase (CYP11B2)Chr8p24.3rs6432*Intronic/Regulatory0.38 0 (n = 13)
1 (n = 1)
2 (n = 0)
4.7 ± 7.3
16.1 ± NA
NA
−3.5 ± 6.0
3.9 ± NA
NA
0 (n = 8)
1 (n = 1)
2 (n = 0)
−2.6 ± 6.9
−6.6 ± NA
NA
−2.1 ± 5.4
1.9 ± NA
NA
rs724991203′ UTR/Intronic/Transcript0.225
rs4545Missense/Coding Transcript0.22
rs4536SynonymousNA
rs3802228*3′ UTRNA 0 (n = 11) 5.5 ± 7.3 −3.9 ± 6.4 0 (n = 2) 1.6 ± 11.4 −1.7 ± 11.6
rs7463212DownstreamNA 1 (n = 2) 0.5 ± 8.3 −1.5 ± 2.7 1 (n = 4) −4.5 ± 7.1 −2.9 ± 4.5
2 (n = 1) 16.8 ± NA 3.9 ± NA 2 (n = 3) −4.1 ± 2.3 0.1 ± 1.6
  • Chromosome location and function obtained from SNAP, SNP Annotation and Proxy Search www.broadinstitute.org/mpg/snap/ldsearch.php; CADD, Combined Annotation‐Dependent Depletion, a score that prioritizes causal variation and regulatory effects www.cadd.gs.washington.edu; SBP, Systolic Blood Pressure; DBP, Diastolic Blood Pressure; UTR, Untranslated Region; NA, Not Available; *Multiple variants with the same # minor allele values.

  • 1X and SD are computed as the average and standard deviation, respectively, of the subject‐level BP response averaged over 19 h. Bolded values correspond to significant effects after multiple testing adjustment.