Table 2. The blood pressure response (X ± SD)1 after versus before VIGOROUS exercise compared to control over 19 h by # of Minor Alleles and Racial/Ethnic Group
Gene name (Gene symbol)Chromosome (Chr) locationVariantFunctionCADD scoreAfrican Americans (n = 14)Caucasians (n = 9)
# Minor AllelesSBPDBP# Minor AllelesSBPDBP
Angiotensinogen Converting Enzyme (ACE)Chr17q23.3rs10550863′ UTRNA 0 (n = 11)
1 (n = 3)
2 (n = 0)
3.7 ± 10.1
20.8 ± 18.2
NA
2.6 ± 5.5
13.7 ± 8.4
NA
0 (n = 4)
1 (n = 3)
2 (n = 2)
2.0 ± 6.5
−1.6 ± 15.3
1.0 ± 14.1
−0.3 ± 3.8
0.4 ± 7.0
−0.8 ± 9.3
Angiotensin Type 1 Receptor (AGTR1)Chr3q24rs74662294Intronic/Intergenic/Upstream9.038 0 (n = 13)
1 (n = 1)
2 (n = 0)
0.6 ± 13.7
30.0 ± NA
NA
0.6 ± 7.6
19.7 ± NA
NA
0 (n = 9)
1 (n = 0)
2 (n = 0)
0.6 ± 10.1
NA
NA
−0.2 ± 5.4
NA
NA
Aldosterone Synthase (CYP11B2)Chr8p24.3rs4546*Synonymous/Coding Transcript1.736 0 (n = 8)
1 (n = 5)
2 (n = 1)
2.3 ± 10.5
−1.9 ± 18.9
−29.8 ± NA
2.8 ± 5.2
3.0 ± 10.0
19.7 ± NA
0 (n = 4)
1 (n = 3)
2 (n = 2)
−2.3 ± 5.6
−2.6 ± 14.8
11.1 ± 0.2
1.6 ± 6.5
−3.0 ± 2.1
0.5 ± 7.5
rs72552275Synonymous/Coding Transcript1.736
rs4539Missense/Coding Transcript0.001
rs4537Missense/Coding Transcript0.001 0 (n = 13)
1 (n = 1)
2 (n = 0)
0.6 ± 13.7
29.8 ± NA
NA
0.6 ± 7.8
19.7 ± NA
NA
0 (n = 9)
1 (n = 0)
2 (n = 0)
0.6 ± 10.1
NA
NA
−0.2 ± 5.4
NA
NA
Adducin (ADD1)Chr4p16.3rs16843169*Synonymous/Coding Transcript13.93 0 (n = 12)
1 (n = 2)
2 (n = 0)
1.4 ± 14.0
19.0 ± 15.2
NA
0.1 ± 7.7
−6.6 ± 18.5
NA
0 (n = 9)
1 (n = 0)
2 (n = 0)
0.6 ± 10.1
NA
NA
−0.2 ± 5.4
NA
NA
rs49693′ UTR/Intergenic/Downstream4.696
rs360389213′ UTR/Intergenic0.112
rs47413′ UTR/Intergenic/Downstream0.298
rs6833874*Intronic/Transcript2.195 0 (n = 10) 4.1 ± 10.6 2.6 ± 6.0 0 (n = 9) 0.6 ± 10.1 −0.2 ± 5.4
rs49663′ UTR/Intergenic/Downstream1.77 1 (n = 4) 15.5 ± 18.4 9.8 ± 10.4 1 (n = 0) NA NA
2 (n = 0) NA NA 2 (n = 0) NA NA
  • Chromosome location and function obtained from SNAP, SNP Annotation and Proxy Search www.broadinstitute.org/mpg/snap/ldsearch.php; CADD, Combined Annotation‐Dependent Depletion, a score that prioritizes causal variation and regulatory effects www.cadd.gs.washington.edu; SBP, Systolic Blood Pressure; DBP, Diastolic Blood Pressure; UTR, Untranslated Region; NA, Not Available; *Multiple variants with the same # minor allele values.

  • 1X and SD are computed as the average and standard deviation, respectively, of the subject‐level BP response averaged over 19 h. Bolded values correspond to significant effects after multiple testing adjustment.