Table 4. Overview and gene ontologies in respect to “Biological Function” of 86 mitochondrial proteins identified to be regulated by diet
Mitochondrial proteins
GO biological functionProtein name
DOWNUP
Heme biosynthesisFECH, PPOX
Programmed cell deathPGAM5
Nucleotide biosynthesisDTYMK
PeptidasesCTSA, CTSB
Purine metabolismUOX, 1190003J15Rik
Sphingolipid metabolic processPSAP
AminotransferaseAGXTOAT, AGXT‐2, GOT2
Amino acid catabolic pathwayAASS, GCATBCKDH, BCKDHB, BCKDHA, MCCC1, DMGDH, GCDH
Fatty acid beta‐oxidationHADHA, CROT, EHHADHACAD10, ACADS, ACAA2, CYB5A, PCCA
Hydroxyacid‐oxoacid transhydrogenaseADHFE1ADHFE1
Inner mitochondrial membrane organizationMINOS1OPA1, LETM1
Mitochondrial translationMRPL24, MRPS5MRPS7
Protein importSAMM50PMPCA
Respiratory chainCYTCS, NDUFS6, NDUFAF4, ATP5DNDUFAF1
Response to oxidative stressCAT, SOD1MSRA, DNAJC11, MGST1
Sulfur metabolismETHE1SUOX, SQRDL
Urea cycleCPS1OTC
Acyl‐CoA ligase activityACSM3, ACSS3, ACSF2, SLC27A2
Calcium homeostasisRMDN3 (Ptpip51)
Cellular aldehyde metabolic processALDH3A2
Glutamate/glutamine metabolismGLUL, GLUD1
Ketone body productionACAT1
Oxidoreductase ‐ heme bindingCYP22D2, AKR7A5, FDXR
TCA cycleSUCLA2, SUCLG2
Transmembrane transportABCB7, MTCH1, SLC25A45, SLC25A10, SLC25A13, SLC25A1
Unknown functionMTFR1L, ADCK1, LRRC59, UPF0640, RMDN2, C14orf159, SND1, ISOC2, MMAA, C21orf33, BPHL, HINT2