Table 1. Relative anion permeability of swelling‐activated anion conductances in zebrafish embryo cells and LRRC8−/− HCT116 cells transfected with LRRC8 cDNAs
Cell typeAnionErev (mV)Px/PCl
Zebrafish embryo cells115 mmol/L Cl−9.1 ± 1.6
115 mmol/L SCN−21.4 ± 3.91.8 ± 0.2
115 mmol/L I−16.5 ± 2.01.5 ± 0.1
58 mmol/L taurine27.2 ± 4.50.19 ± 0.04
LRRC8−/− HCT116 cells transfected with human LRRC8A and human LRRC8C cDNAs70 mmol/L Cl12.0 ± 0.9
70 mmol/L SCN−2.8 ± 1.61.8 ± 0.07
70 mmol/L I4.4 ± 0.91.3 ± 0.05
58 mmol/L taurine52.1 ± 2.30.21 ± 0.02
LRRC8−/− HCT116 cells transfected with zebrafish lrrc8aa and human LRRC8C cDNAs70 mmol/L Cl12.0 ± 1.1
70 mmol/L SCN−0.9 ± 1.41.7 ± 0.05
70 mmol/L I2.4 ± 0.91.5 ± 0.05
58 mmol/L taurine50.4 ± 1.70.23 ± 0.01
  • Values are means ± SE (n = 4–6).